LOCUS       1709462       617 aa                              01-NOV-1997
DEFINITION  MITOCHONDRIAL PRECURSOR PROTEINS IMPORT RECEPTOR (70 KD
            MITOCHONDRIAL OUTER MEMBRANE PROTEIN) (TRANSLOCASE OF OUTER
            MEMBRANE TOM70).
ACCESSION   1709462
PID         g1709462
DBSOURCE    SWISS-PROT: locus OM70_YEAST, accession P07213
            class: standard.
            created: Apr 1, 1988.
            sequence updated: Oct 1, 1996.
            annotation updated: Nov 1, 1997.
            xrefs: gi: 4081, gi: 4082, gi: 1183941, gi: 1302049, gi: 2144929
            xrefs (non-sequence databases): SGD L0001030, SGD L0003141
KEYWORDS    MITOCHONDRION; OUTER MEMBRANE; TRANSMEMBRANE; TPR DOMAIN.
SOURCE      baker's yeast.
  ORGANISM  Saccharomyces cerevisiae
            Eukaryotae; Fungi; Ascomycota; Hemiascomycetes; Saccharomycetales;
            Saccharomycetaceae; Saccharomyces.
REFERENCE   1  (residues 1 to 617)
  AUTHORS   Hase,T., Riezman,H., Suda,K. and Schatz,G.
  TITLE     Import of proteins into mitochondria: nucleotide sequence of the
            gene for a 70-kd protein of the yeast mitochondrial outer membrane
  JOURNAL   EMBO J. 2 (12), 2169-2172 (1983)
  MEDLINE   84131928
  REMARK    SEQUENCE FROM N.A.
REFERENCE   2  (residues 1 to 617)
  AUTHORS   De Antoni,A., D'Angelo,M., Dal Pero,F., Sartorello,F., Pandolfo,D.,
            Pallavicini,A., Lanfranchi,G. and Valle,G.
  TITLE     The DNA sequence of cosmid 14-13b from chromosome XIV of
            Saccharomyces cerevisiae reveals an unusually high number of
            overlapping open reading frames
  JOURNAL   Yeast 13 (3), 261-266 (1997)
  MEDLINE   97245296
  REMARK    SEQUENCE FROM N.A.
REFERENCE   3  (residues 1 to 617)
  AUTHORS   Boguski,M.S., Sikorski,R.S., Hieter,P. and Goebl,M.
  TITLE     Expanding family
  JOURNAL   Nature 346 (6280), 114 (1990)
  MEDLINE   90309987
  REMARK    TPR REPEATS.
REFERENCE   4  (residues 1 to 617)
  AUTHORS   Hines,V., Brandt,A., Griffiths,G., Horstmann,H., Brutsch,H. and
            Schatz,G.
  TITLE     Protein import into yeast mitochondria is accelerated by the outer
            membrane protein MAS70
  JOURNAL   EMBO J. 9 (10), 3191-3200 (1990)
  MEDLINE   91006012
  REMARK    CHARACTERIZATION.
REFERENCE   5  (residues 1 to 617)
  AUTHORS   Hines,V. and Schatz,G.
  TITLE     Precursor binding to yeast mitochondria. A general role for the
            outer membrane protein Mas70p
  JOURNAL   J. Biol. Chem. 268 (1), 449-454 (1993)
  MEDLINE   93107043
  REMARK    CHARACTERIZATION.
COMMENT     On Dec 6, 1996 this sequence version replaced gi:129114.
            [FUNCTION] RECEPTOR THAT ACCELERATES THE IMPORT OF ALL
            MITOCHONDRIAL PRECURSOR PROTEINS. THOUGHT TO ACT IN CONJUNCTION
            WITH MAS37.
            [SUBUNIT] FORMS PART OF THE RECEPTOR COMPLEX THAT CONSISTS OF AT
            LEAST 8 DIFFERENT PROTEINS (TOM5, TOM6, TOM7, TOM20, TOM22, TOM37,
            TOM40 AND TOM70). FORMS A HETERODIMER WITH MAS37.
            [SUBCELLULAR LOCATION] INTEGRAL MEMBRANE PROTEIN. MITOCHONDRIAL
            OUTER MEMBRANE.
            [SIMILARITY] CONTAINS 7 COPIES OF THE TPR DOMAIN.
FEATURES             Location/Qualifiers
     source          1..617
                     /organism="Saccharomyces cerevisiae"
                     /db_xref="taxon:4932"
                     1..617
     Protein         1..617
                     /product="MITOCHONDRIAL PRECURSOR PROTEINS IMPORT
                     RECEPTOR"
     Region          1..10
                     /note="INTERMEMBRANE."
                     /region_name="Domain"
     Region          11..30
                     /region_name="Transmembrane region"
     Region          31..617
                     /note="CYTOPLASMIC."
                     /region_name="Domain"
     Region          99..131
                     /note="TPR 1."
                     /region_name="Repetitive region"
     Region          132..165
                     /note="TPR 2."
                     /region_name="Repetitive region"
     Region          185
                     /note="A -> R (IN REF. 1)."
                     /region_name="Conflict"
     Region          363..396
                     /note="TPR 3."
                     /region_name="Repetitive region"
     Region          397..430
                     /note="TPR 4."
                     /region_name="Repetitive region"
     Region          465..498
                     /note="TPR 5."
                     /region_name="Repetitive region"
     Region          508..541
                     /note="TPR 6."
                     /region_name="Repetitive region"
     Region          542..575
                     /note="TPR 7."
                     /region_name="Repetitive region"
ORIGIN      
        1 mksfitrnkt ailatvaatg taigayyyyn qlqqqqqrgk kntinkdekk dtkdsqkete
       61 gakkstapsn ppiypvssng epdfsnkanf taeekdkyal alkdkgnqff rnkkyddaik
      121 yynwalelke dpvfysnlsa cyvsvgdlkk vvemstkale lkpdyskvll rrasaneglg
      181 kfadamfdls vlslngdfnd asiepmlern lnkqamsklk ekfgdidtat atptelstqp
      241 akerkdkqen lpsvtsmasf fgifkpeltf anydesnead kelmnglsnl ykrspesydk
      301 adesftkaar lfeeqldknn edeklkekla islehtgifk flkndplgah edikkaielf
      361 prvnsyiyma limadrndst eyynyfdkal kldsnnssvy yhrgqmnfil qnydqagkdf
      421 dkakeldpen ifpyiqlacl ayrenkfddc etlfseakrk fpeapevpnf faeiltdknd
      481 fdkalkqydl aielenkldg iyvgiaplvg katlltrnpt venfieatnl lekaskldpr
      541 seqakiglaq mklqqedide aitlfeesad lartmeeklq aitfaeaakv qqrirsdpvl
      601 akkiqetlak lreqglm
//

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