LOCUS       1730068       606 aa                              01-OCT-1996
DEFINITION  A-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE (ONCOGENE
            PKS2).
ACCESSION   1730068
PID         g1730068
DBSOURCE    SWISS-PROT: locus KRAA_HUMAN, accession P10398
            class: standard.
            created: Mar 1, 1989.
            sequence updated: Oct 1, 1996.
            annotation updated: Oct 1, 1996.
            xrefs: gi: 28820, gi: 508473, gi: 780127, gi: 1405976, gi: 1405977,
            gi: 625217
            xrefs (non-sequence databases): MIM 311010, PROSITE PS00107,
            PROSITE PS00108, PROSITE PS00479, PROSITE PS50011
KEYWORDS    TRANSFERASE; SERINE/THREONINE-PROTEIN KINASE; PROTO-ONCOGENE; ZINC;
            ATP-BINDING; PHORBOL-ESTER BINDING.
SOURCE      human.
  ORGANISM  Homo sapiens
            Eukaryotae; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
            Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 606)
  AUTHORS   Beck,T.W., Huleihel,M., Gunnell,M., Bonner,T.I. and Rapp,U.R.
  TITLE     The complete coding sequence of the human A-raf-1 oncogene and
            transforming activity of a human A-raf carrying retrovirus
  JOURNAL   Nucleic Acids Res. 15 (2), 595-609 (1987)
  MEDLINE   87146380
  REMARK    SEQUENCE FROM N.A.
REFERENCE   2  (residues 1 to 606)
  AUTHORS   Lee,J.E., Beck,T.W., Brennscheidt,U., DeGennaro,L.J. and Rapp,U.R.
  TITLE     The complete sequence and promoter activity of the human A-raf-1
            gene (ARAF1)
  JOURNAL   Genomics 20 (1), 43-55 (1994)
  MEDLINE   94292185
  REMARK    SEQUENCE FROM N.A.
            TISSUE=PLACENTA
COMMENT     On Dec 12, 1996 this sequence version replaced gi:125645.
            [FUNCTION] INVOLVED IN THE TRANSDUCTION OF MITOGENIC SIGNALS FROM
            THE CELL MEMBRANE TO THE NUCLEUS.
            [TISSUE SPECIFICITY] PREDOMINANTLY IN UROGENITAL TISSUES (BY
            SIMILARITY).
            [SIMILARITY] WITH THE CONSERVED CATALYTIC DOMAINS OF
            SER/THR-PROTEIN KINASES. BELONGS TO THE MIL/RAF SUBFAMILY.
            [SIMILARITY] CONTAINS A COPY OF THE ZINC-DEPENDENT PHORBOL-ESTER
            AND DAG BINDING DOMAIN.
FEATURES             Location/Qualifiers
     source          1..606
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     1..606
     Protein         1..606
                     /product="A-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN
                     KINASE"
                     /EC_number="2.7.1.-"
     Region          99..144
                     /note="PHORBOL-ESTER AND DAG BINDING."
                     /region_name="Domain"
     Region          310..570
                     /note="PROTEIN KINASE."
                     /region_name="Domain"
     Site            316..324
                     /note="ATP."
                     /site_type="np-binding"
     Site            336
                     /note="ATP."
                     /site_type="binding"
     Site            429
                     /site_type="active"
ORIGIN      
        1 mepprgppan gaepsravgt vkvylpnkqr tvvtvrdgms vydsldkalk vrglnqdccv
       61 vyrlikgrkt vtawdtaiap ldgeelivev ledvpltmhn fvrktffsla fcdfclkflf
      121 hgfrcqtcgy kfhqhcsskv ptvcvdmstn rqqfyhsvqd lsggsrqhea psnrplnell
      181 tpqgpsprtq hcdpehfpfp apanaplqri rststpnvhm vsttapmdsn liqltgqsfs
      241 tdaagsrggs dgtprgspsp asvssgrksp hskspaeqre rksladdkkk vknlgyrdsg
      301 yywevppsev qllkrigtgs fgtvfrgrwh gdvavkvlkv sqptaeqaqa fknemqvlrk
      361 trhvnillfm gfmtrpgfai itqwcegssl yhhlhvadtr fdmvqlidva rqtaqgmdyl
      421 hakniihrdl ksnniflheg ltvkigdfgl atvktrwsga qpleqpsgsv lwmaaevirm
      481 qdpnpysfqs dvyaygvvly elmtgslpys higcrdqiif mvgrgylspd lskissncpk
      541 amrrllsdcl kfqreerplf pqilatiell qrslpkiers asepslhrtq adelpaclls
      601 aarlvp
//

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